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KMID : 0618720090150010057
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Journal of The Korea Institute of Oriental Medicine Informatics
2009 Volume.15 No. 1 p.57 ~ p.66
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Wound Healing-Enhancing and Anti-inflammatory effects of five Korean Traditional Herbal Medicines, Jeong Yang-dan
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Cho Ga-Young
Rho Ho-Sik
Kim Eun-Joo
Moon Eun-Jeong
Kim Ji-Seong
Park Hye-Yoon
Kim Duck-Hee
Kim Han-Gon
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Abstract
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Objectives : The aim of the present study is to evaluate the wound healing-enhancing and anti-inflammatory effects of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensison human keratinocyte, HaCaT cells.
Methods : We adopted in vitro wound healing assay to measure the proliferation-and migration-enhancing effects in HaCaT cells. The expressions of cytokine genes were measured in HaCaT cells using real-time PCR analysis.
Results : The extracts of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensis enhanced the proliferation and migration of HaCaTcells. The expression of keratinocyte growth factor receptor(FGFR2-IIIb) gene was also induced. The extracts inhibited iNOS, IL- and TNF- gene expression.
Conclusions : The extract of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensis has wound healing-enhancing effects and anti-inflammatory effects.
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KEYWORD
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Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum, Scutellaria baikalensis, HaCaT keratinocytes, wound healing, anti-inflammation
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